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pentobarbital will lower the extent or effect of osilodrostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the extent or effect of siponimod by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of siponimod by using a drug that triggers moderate CYP2C9 moreove
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